At the crossroad of bio-engineering and microelectronics, we develop unique “Intelligent Stents” that can continuously monitor blood vessel stenosis and patency. As a second step, we will implement in-situ miniaturized pulse-generating system for electroporation allowing targeted gene therapy. On the road towards this ambitious goal, we produce low cost portable electroporators for the need of cell therapies. Further, the advanced microelectronics have multiple other HMI applications, as brain machine interface, prosthetics fordisabled patients (detection and stimulation).