The EVB represents the next generation of tissue-engineered blood vessels, incorporating advanced multi-channel electrodes that enable bidirectional electric potential transmission. With its combined therapeutic and monitoring capabilities, the EVB offers a range of benefits for patients suffering from vascular diseases.
By stimulating the blood vessel with electric pulses, the E-VB is able to transfect embedded genes into the tissue, enhancing its performance and encoding other functions. For example, by transfecting the β Cell Gene Atlas (BCGA) or substitutional glucose regulation gene network into the blood vessel, the E-VB has the potential to serve as a treatment for diabetics.
In addition to its therapeutic capabilities, the EVB is also able to retrieve information from the blood vessel, such as its patency and pressure. This information can be critical for monitoring the health of patients and ensuring the long-term success of the treatment.
A biocompatible electric circuit with high stretchability is developed
The development of a flexible, biocompatible circuit has paved the way for implantable integrated circuits, allowing for applications such as electroporation.
The technology is applied to the extravascular stent
Through the use of electroporation, the flexible stent is able to accelerate endothelialization and prevent the development of intimal hyperplasia following CABG surgery.
Experiments ran in small animal models
Proof of concept was demonstrated in rabbits, and the technology exhibits remarkable potential for restoring post-surgical patency.
The electronic blood vessel is invented in our lab
The possibility of using an implantable electric circuit to enhance the functionality of blood vessels is explored. The interface is able to send and receive local electric signals.
Roumai GMP standard manufacturing lab is established in Shenzhen
Large-scale studies can be performed concurrently with explorations into various materials and the design of electric interfaces.
Collaboration with research centers for the creation of IC interface
Collaboration with leading research institutes from diverse fields is ongoing to minimize critical components for E-BV.
Capable of using gene editing technology for suppression or cure of the lesion.
Using electric potential to stimulate the tissue for faster healing.
Always keep the patients in check, easily monitor the patency and pressure at home.
Long term monitoring
Third-generation vascular graft
E-BV: A seamless interface for a blood vessel evolution
A reliable human-machine interface for treating intractable diseases.